3 txoj hauv kev zoo siab uas chemists tsim cov tebchaw xyoo no
los ntawm Bethany Halford
EVOLVED ENZYMES UA HAUJ LWM BIARYL BONDS
Scheme qhia ib qho enzyme-catalyzed biaryl coupling.
Chemists siv biaryl molecules, uas feature aryl pawg tethered rau ib leeg los ntawm ib daim ntawv cog lus, raws li chiral ligands, cov ntaub ntawv tsev blocks, thiab tshuaj.Tab sis ua rau lub biaryl motif nrog hlau-catalyzed cov tshuaj tiv thaiv, xws li Suzuki thiab Negishi cross-couplings, feem ntau yuav tsum tau ob peb kauj ruam hluavtaws los ua cov neeg koom tes sib txuas.Dab tsi ntxiv, cov hlau-catalyzed cov tshuaj tiv thaiv tsis zoo thaum ua cov biaryls loj.Kev tshoov siab los ntawm enzymes 'muaj peev xwm ua kom muaj kev cuam tshuam, ib pab pawg coj los ntawm University of Michigan's Alison RH Narayan tau siv cov kev hloov pauv los tsim cov cytochrome P450 enzyme uas tsim cov biaryl molecule ntawm oxidative coupling ntawm aromatic carbon-hydrogen bonds.Lub enzyme weds aromatic molecules los tsim ib stereoisomer nyob ib ncig ntawm ib daim ntawv cog lus nrog hindered rotation (pom).Cov kws tshawb fawb xav tias txoj hauv kev biocatalytic no tuaj yeem dhau los ua kev hloov pauv ntawm lub khob cij thiab butter rau kev ua biaryl bonds (Nature 2022, DOI: 10.1038 / s41586-021-04365-7).
Daim ntawv qhia rau TERTIARY AMINES tso siab rau me ntsis ntsev
Scheme qhia cov tshuaj tiv thaiv uas ua rau tertiary amines los ntawm cov theem nrab.
Kev sib xyaw electron-tshaib plab hlau catalysts nrog electron-nplua nuj amines feem ntau tua cov catalysts, yog li hlau reagents tsis tuaj yeem siv los tsim tertiary amines los ntawm theem nrab amines.M. Christina White thiab cov npoj yaig ntawm University of Illinois Urbana-Champaign paub tias lawv tuaj yeem nyob ib puag ncig qhov teeb meem no yog tias lawv ntxiv qee cov ntsev ntsev rau lawv daim ntawv qhia reactant.Los ntawm kev hloov cov amines theem nrab mus rau hauv ammonium ntsev, cov kws tshuaj pom tau tias lawv tuaj yeem ua rau cov tshuaj no nrog terminal olefins, oxidant, thiab palladium sulfoxide catalyst los tsim myriad tertiary amines nrog ntau pawg ua haujlwm (piv txwv li pom).Cov kws kho mob tau siv cov tshuaj tiv thaiv los ua cov tshuaj tiv thaiv kev puas siab puas ntsws Abilify thiab Semap thiab hloov cov tshuaj uas twb muaj lawm uas yog cov tshuaj thib ob, xws li cov tshuaj tiv thaiv kev nyuaj siab Prozac, mus rau qib amines, ua kom pom tias cov kws kho mob yuav ua li cas cov tshuaj tshiab tawm ntawm cov uas twb muaj lawm (Science 2022, DOI: 10.1126/science.abn8382).
AZAARENES POM CARBON CONTRACTION
Scheme qhia quinoline N-oxide hloov mus rau N-acylindole.
Xyoo no chemists ntxiv rau lub repertoire ntawm molecular kho, uas yog cov tshuaj tiv thaiv uas hloov mus rau lub cores ntawm complex molecules.Hauv ib qho piv txwv, cov kws tshawb fawb tau tsim qhov kev hloov pauv uas siv lub teeb thiab cov kua qaub los txiav cov pa roj carbon monoxide ntawm 6-tus tswv cuab azaarenes hauv quinoline N-oxides los ua N-acylindoles nrog tsib-membered rings (piv txwv li pom).Cov tshuaj tiv thaiv, tsim los ntawm chemists hauv Mark D. Levin pawg ntawm University of Chicago, yog raws li cov tshuaj tiv thaiv uas koom nrog lub teeb mercury, uas tso tawm ntau lub teeb ntawm lub teeb.Levin thiab cov npoj yaig tau pom tias siv lub teeb-emitting diode uas emits lub teeb ntawm 390 nm muab lawv tswj tau zoo dua thiab tso cai rau lawv ua kom cov tshuaj tiv thaiv dav dav rau quinoline N-oxides.Cov tshuaj tiv thaiv tshiab muab cov neeg tsim cov molecule ib txoj hauv kev los kho cov cores ntawm complex compounds thiab tuaj yeem pab cov kws tshuaj kho mob nrhiav kom nthuav lawv cov tsev qiv ntawv ntawm cov neeg sib tw tshuaj (Science 2022, DOI: 10.1126/science.abo4282).
Post lub sij hawm: Dec-19-2022